hepatic triglyceride lipase
Summary
Hepatic lipase (HTGL) hydrolyzes triglycerides and phospholipids in chylomicron remnants, IDL, and HDL, playing a critical role in remnant clearance and HDL remodeling. Deficiency causes remnant accumulation and premature atherosclerosis.
Detail
HTGL is synthesized by liver sinusoidal endothelial cells and catalyzes hydrolysis of triglycerides in triglyceride-rich lipoproteins. In chylomicron remnant metabolism, HTGL removes triglycerides to facilitate hepatic uptake. In HDL metabolism, HTGL remodels HDL by hydrolyzing triglycerides and phospholipids. HTGL deficiency results in accumulation of remnant-like particles, hypertriglyceridemia, and accelerated atherosclerosis. Activity is reduced in type 2 diabetes and hypothyroidism.
Sources
- First Aid for the USMLE Step 1
- Robbins Basic Pathology
- Harrison's Principles of Internal Medicine
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